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KMID : 0043320120350020375
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Archives of Pharmacal Research
2012 Volume.35 No. 2 p.375 ~ p.382
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Age-related effects of sodium arsenite on splenocyte proliferation and Th1/Th2 cytokine production
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Cho Yu-Ri
Ahn Kyong-Hoon
Back Moon-Jung
Choi Jong-Min
Ji Jung-Eun
Won Jong-Hoon
Fu Zhicheng
Jang Ji-Min
Kim Dae-Kyong
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Abstract
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Aging is associated with immune dysfunction and conditions such as inflamm-aging and immunosuppression. Arsenic, an environmental contaminant distributed worldwide, affects the immune system. This study tested the hypothesis that arsenic has distinct effects on T cell proliferation and the production of cytokines by activated T cells. Murine splenocytes from young (2 months) and aged (24?26 months) C57BL/6 mice were exposed to arsenite (As3+), the most toxic form of inorganic arsenic, and stimulated with concanavalin A (Con A) or anti-CD3 antibody. T cell proliferation decreased significantly in response to Con A and anti-CD3 at subtoxic doses of arsenite in splenocytes from both young and aged mice. Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-γ (IFN-γ), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice. In contrast, the production of IL-2 and IL-4 by splenocytes from aged mice was only slightly affected by arsenite. The results show that arsenic exposure reduces the immune response in splenocytes. Moreover, this effect may be influenced by aging.
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KEYWORD
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Aging, Arsenicl, Heavy metal, Immunotoxicity, Splenocyte, Cytokine
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